Integrating design and function
Learn how our intuitively designed cartridge architecture incorporates the versatile Xceler8™ Technology to fully automate nucleic acid extraction and markedly simplify molecular research and testing.
Breakthrough technology for beyond simple automation
Representing a departure from conventional, labor-intensive and time-consuming sample preparation methods, the disruptive Xceler8 Technology allows users to extract and purify nucleic acids from a variety of human, bacterial and viral samples at the push of a button.
Unlike typical commercial spin-column or magnetic-bead technologies, the automated Xceler8 Technology uses a novel four-step chemistry-based approach to purify nucleic acids.
Once the sample has been added and the X8 Cartridge inserted into the Instrument, a preloaded lysis buffer is automatically mixed with the sample and loaded into the channel. Incubation with the buffer lyses the cells to liberate the nucleic acids.
A reversible crosslinker then selectively binds and clusters the nucleic acids on to the solid surface of the main channel, forming a loose 3-D network.
Wash away impurities
Impurities and cellular debris are then washed away and sealed in a waste reservoir within the cartridge, leaving behind purified nucleic acids, thereby simplifying clean-up and minimizing contamination.
Elute nucleic acid
The purified nucleic acids are then released from the surface of the channel and eluted into the collection tube, now ready for a wide range of research and clinical applications.
High DNA yield with the X8 Genomic DNA Cartridge Kit
Genomic DNA extraction performance using X8 vs competitor manual kits. Agarose gel analysis of purified DNA from cell culture, gram- & gram+ bacterial cultures; Quantified DNA yield & RT-PCR data from various gram+ bacterial cultures; Ct values (inversely proportional to yield).